Full professor - Université de Sherbrooke
Department of biochemistry,
Faculty of medicine and health science
Our research theme is focused on the determination of the genetic impact of spermatid chromatin remodelling. We have highlighted the formation of double strand DNA breaks during this important structural transition and hypothesized that the repair of these breaks is a source of genetic instability since their repair cannot rely on sister chromatid in this haploid context.
Our objective is thus to map these breaks through high throughput sequence and to determine whether the structural transition really induces de novo polymorphism at break sites, which could highlight a new evolutionary component. We intend to determine the mechanism involved in the repair of transitory breaks as well as the impact of physiological changes, such as aging, on their distribution and mutagenicity. The spermatid chromatin structure change requires the eviction of histones and relies on their massive acetylation.
One of our parallel projects consist in determining the mechanism through which histones become globally, and not specifically, hyperacetylated during chromatin remodelling. We are exploring non enzymatic acetylation which could involve the regulation of acetyl-CoA pools by mitochondrial acetyltransferases relocated to the nucleus. Other projects are currently being developed and involve the etiology of disorders in the spectrum of autism as well as the study of parameters involved in the initiation of genetic instability in carcinogenesis.
ExpertiseMale gametogenesis DNA repair Chromatin structure
Centre Hospitalier de l'Université de Sherbrooke3201 rue Jean-Mignault
Sherbrooke (QC) Canada
(819) 821-8000 extension : 75443
Fax : (819) 820-6831
Postdoctoral fellowship: University of California (San Francisco, CA, USA)
PhD: Université Laval (Québec, QC, Canada)
Transient fragmentation of DNA during gametogenesis of the fission yeast Schizoccharomyces pombe
Genetic instability at suboptimal pH
Nuclear isofrom of carnitin acetyltransferase and chromatin
Spermatid genetic instability and doublebrake DNA repair
Cassures transitoires de l'ADN du spermatide: cartographie et polymorphisme de novo