Delbès, Géraldine PhD - Regular researcher


Professor - Centre INRS–Institut Armand-Frappier

INRS–Institut Armand-Frappier

Research interest

Our research projects aim to determine how exposition to medical or environmental compounds, during specific sensitive periods of the life cycle, can affect male fertility. Epidemiologic data suggest a worldwide increase in male fertility problems associated to a decrease of sperm production, an increase in the incidence of testicular cancer and developmental abnormalities in the development of the male reproductive tract in human and many wildlife species. Data demonstrating a negative impact of exposition to chemical compounds found in the environment or used for medical procedures on the male reproductive function are accumulating. However, the cellular and molecular mechanisms involved on these impacts on male fertility are poorly documented. We are working on the characterization of these mechanisms in immature germinal cells, spermatogenesis precursors. Using rodent and human in vivo and in vitro models, we study gene expression in the programming of germinal cells, in response to the chemical environment.  

 

Expertise

Gonocytes Epigenetics Perinatal life Male fertility Endocrine disruptors Toxicology Chemotherapy development

Centre INRS–Institut Armand-Frappier

Pavillon de la Recherche et de la Formation
Édifice 18
531 boulevard des Prairies,
Laval (QC) Canada
H7V 1B7
(450) 687-5010 extension : 8830
Fax : (450) 686-5501
geraldine.delbes@iaf.inrs.ca

Postdoctoral fellowship: Department of Phamacology and Therapeutics, McGill University (Montreal, Qc, Canada  )

PhD: Reproduction et Développement, Université paris Sud (Paris, France)

MSc:  DEA de Physiologie de la Reproduction à l’Université Pierre et Marie Currie (Paris, France)

Undergraduate: Biologie Cellulaire et Physiologie à l’Université Denis Diderot (Paris, France)


Direction
Tardif, Sarah - Master - Studies in progress
Subject :

Recherche de substituts sécuritaires aux perturbateurs endocriniens



Direction
Rwigemera, Arlette - PhD - Studies in progress
Subject :

Étude in vitro de l’effet des xénoestrogènes sur la reprogrammation épigénétique dans les cellules germinales foetales du rat mâle

Elomri, Rhizlane - PhD - Studies in progress
Baalbaki, Ghida - PhD - Studies in progress
Subject :

Effet des contaminants associés à la fracturation hydraulique sur la grossesse et le développement fœtal




3 Latest projects

  • Périnatalité et transition à la parentalité en période de pandémie de COVID-19 – du social au moléculaire.
  • Analyse ciblée de la méthylation d'ADN dans la lignée germinale mâle pour le dépistage de l'influence environnementale
  • CRSNG - Discovery Grant individual, Molecular mechanism by which estrogens affect male germ cell programming during development

2 Latest projects

  • Gestational exposure to chemicals related to hydraulic fracturing in Northeastern British Columbia, and their endocrine disrupting potential
  • Endocrine Disrupting Chemicals: Towards Responsible Replacements