Full professor - Université Laval
Department of animal science,
Institute of nutrition and functional foods,
Faculty of agriculture and food science
My research program is composed of two main axes. The first one begin the definition of oocyte and early embryo quality determinants. The fact that the ability of the oocyte to become an embryo is acquired when the gamete is still in the ovarian follicle is well known. The ovarian follicle is composed of about four cellular types and we are interested in the cells closer to the oocyte by studying their ability to sustain the development and preparation of the gamete. We are also interested in the RNA pools stored in the oocyte and used to sustain the first cellular divisions. To this day, the storing, management and disposal mechanism for these RNA pools are not well understood. This despite the fact that the majority of embryos die during the first cellular divisions while these stocks support cellular functions.
Our second research axis revolves around genetic related aspects such as genomics (studying DNA as a whole), including genomic diversity analysis and the impact of epigenetic, especially DNA methylation, on gene expression and thus phenotypes. Representative examples of our projects in this axis are the analysis of the genetic diversity of the Canadienne cow breed or the impact of the environment (such as the one being affected by the mother’s nutrition) on embryo quality and the establishment of its epigenome; more precisely on the DNA methylation marks that will influence gene expression, including a range of long non-coding RNA.
ExpertiseEarly embryonic development Genetics Genomics Maternal RNA management Oocyte quality
Pavillon Paul-Comtois2425 rue de l'Agriculture
Université Laval, Local 4217
Québec (QC) G1V 0A6
(418) 656-2131 extension : 412842
Fax : (418) 656-5877
Postoctoral fellowship: Biomedical Sciences, University of Guelph (Guelph, Ontario, Canada)
PhD: Sciences Animales, Université Laval (Québec, Québec, Canada)
MSc: Sciences Animales, Université Laval (Québec, Québec, Canada)
Undergraduate: Biochimie, Université de Sherbrooke (Sherbrooke, Québec, Canada)
Professionnels de recherche
La science médico-légale qui se cache derrière la validation de la puce à SNPs du caribou (Rangifer)
Développement d'une nouvelle méthode de caryotypage chez le porc
Impact des facteurs neurotrophiques sur la folliculogenèse et l’ovogenèse.
Amélioration des caractères de santé et fertilité chez la vache laitière par une approche génomique alternative
Implication des protéines de la famille fragile X dans la formation des projections du réseau transzonal
Characterization of long non-coding RNAs in follicular cells, oocytes and early bovine embryos
Étude du profil épigénétique spermatique humain au cours de la maturation post-testiculaire
Epigenetic biomarkers screening of bull fertility
Transcriptomic signature of ovarian follicles associated with failed in vitro fertilization attempts in women.