Team
Full professor - Université Laval
Department of animal science,
Institute of nutrition and functional foods,
Faculty of agriculture and food science
Research interest
Journeay to the center of the follicle
The main focus of our research is oocyte competency, which essentially depends on its accompanying follicle. Our genomic tools enable the discovery and study of markers for good follicles in both bovine and human in order to improve procedures, especially in vitro fertilization.
It appears that the mammalian ovary can determine whether the oocyte will be a good one. It now also appears that endogenous and exogenous (injection) hormones can affect follicular quality and incidentally that of the oocyte. The same would be true of environmental conditions such as the mother’s nutrition or her metabolic status. We are interested in understanding who genes react to these conditions and how the ovary can then modify the epigenomic signature of the oocyte to transmit this information.
Our studies are follow up by transcriptome (the set of genes express in a tissue) and epigenome (the packaging of each gene in a tissue) analyses in early bovine embryos using the new EmbryoGENE platform. These analyses enable us to measure the impact of all of the possible manipulation on an embryo, from simple culture to cloning or transgenesis.
Expertise
Granulosa cells Cumulus cells Oocyte competence Competence markers Transcriptomics Embryo Epigenetics Genomics Ovary OvuleINAF/ Pavillon des Services
2440 boul Hochelaga, Local 2732Université Laval
Québec (Québec), G1V 0A6
(418) 656-2131 extension : 407359
Fax : (418) 656-5877
marc-andre.sirard@fsaa.ulaval.ca
Research chair
Chaire de Recherche du Canada en Génomique de la Reproduction
Others links
http://www.vrrc.ulaval.ca/fileadmin/ulaval_ca/Images/recherche/bd/chercheur/fiche/16444.htmlhttp://www.vrrc.ulaval.ca/fileadmin/ulaval_ca/Images/recherche/bd/chercheur/fiche/16444.html
http://www.rqr.umontreal.ca/index.php/en/members/marc-andre-sirard
Postdoctoral fellowship: Animales Sciences, Wisconsin University (Madison, WI, USA)
PhD: Médecine expérimentale, Université Laval (Québec, QC, Canada)
Veterinary medicine: École de médecine vétérinaire, Université de Montréal (Saint-Hyacinthe, QC, Canada)
Professionnels de recherche
Direction
Subject :
Étude de l’impact de l’environnement sur la méthylation de l’ADN mitochondrial et sur le métabolisme du jeune embryon.
Direction
Subject :
The effect of bulls age on sperm methylation, small RNAs and embryo gene expression
Subject :
Comparaison de vaches issues de fécondation in vitro et d'insémination artificielle pour les critères de santé, fertilité et productivité
Subject :
Effet de la mélatonine sur l'axe reproductif chez les ruminants
Subject :
Exploration of the role of lipids in culture media and its relation to epigenetics in bovine reproduction
Subject :
Caractérisation des voies de signalisation PKA et PKC dans les cellules de la granulosa humain en culture
Subject :
Transcriptomic signature of ovarian follicles associated with failed in vitro fertilization attempts in women.
Direction
Subject :
Analysis of mitochondrial methylation patterns in oocytes and embryos using the bovine model