- Date de publication : 2018-04-10
Sirard MA. 40 years of bovine IVF in the new genomic selection context. Reproduction. 2018 Apr 10. pii: REP-18-0008. doi: 10.1530/REP-18-0008. [Epub ahead of print] PubMed PMID: 29636405.
The development of a complex technology such as in vitro fertilization (IVF) requires years of experimentation, sometimes comparing several species to learn how to create the right in vitro environment for oocytes, spermatozoa, and early embryos. At the same time, individual species characteristics such as gamete physiology and gamete interaction are recently evolved traits and must be analysed within the context of each species. In the last 40 years since the birth of Louise Brown, IVF techniques progressed and are now used in multiple domestic and non-domestic animal species around the world. This does not mean that the technology is completely matured or satisfactory; a number of problems remain to be solved and several procedures still need to be optimized. The development of IVF in cattle is particularly interesting since agriculture practices permitted the commercial development of the procedure and it is now used at a scale comparable to human IVF (millions of newborns). The genomic selection of young animals or even embryos combined with sexing and freezing technologies is driving a new era of IVF in the Dairy sector. The time has come for a retrospective analysis of the success and pitfalls of the last 40 yearsof bovine IVF and for the description of the challenges to overcome in the years to come.