Tremblay, Yves PhD- Chercheur régulier


Professeur titulaire- Université Laval

(1) Axe reproduction, santé de la mère et de l'enfant, Centre de recherche du CHU de Québec

(2) Département d'obstétrique, gynécologie et reproduction, Faculté de médecine

-Président de l'Association internationnal et interdisciplinaire sur la chaîne des médicaments

-Membre du conseil d’administration (CA) et du conseil scientifique (CS) de la CIDMEF (Conférence Internationale des Doyens et des facultés de médecine d’expression française)

Intérêts de recherche

The development of my research expertise has been directly related to fetal development and gene expression of steroidogenesis-specific enzymes involved in the metabolism of steroid hormones in gonads, adrenals and peripheral tissues, namely both placenta and fetal lungs. Androgens synthesized by the fetal lungs, estradiol synthesized by the placenta and regulation of the fetal lungs by glucocorticoids do control key events in fetal development by means of their tissue specific expression. In all cases, a spatio-temporal disruption in the synthesis or inactivation or metabolism of androgens and estrogens during pregnancy and a deregulation of glucocorticoid action in the fetal lungs is directly related to developmental pathologies. During fetal development our researches focus on two neonatal pathologies of the lung; the respiratory distress syndrome (RDS) and the bronchopulmonary dysplasia (BPD). More recently, looking at the role of androgens during alveolar process, we open the door for a critical role for male sex steroids on a complication of the chronic obstructive pulmonary disease (COPD) namely emphyzema. This research has specific aspects that hold potential for clinical applications: studying the metabolism and the regulation of steroid hormones by the lungs and placenta are applicable to physiology, while their actions on fetal development, and, more specifically, lung maturation, has clinical potential in the area of human health.

Expertises

Développement et maturation du poumon Développement foetal Métabolisme et action des stéroïdes Physiologie du placenta Syndrome de détresse respiratoire Bronchodysplasie pulmonaire

Centre de recherche du CHU de Québec (CHUL)

2705 boul. Laurier
Québec (QC) Canada
G1V 4G2
(418) 525-4444 poste : 4615
Fax : 418-654-2761
yves.tremblay@crchul.ulaval.ca

POSTDOCTORAT: Université Louis-pasteur-Strasbroug (Strasbourg, France)

POSTDOCTORAT: Institut de recherches cliniques de Montréal (IRCM, Montréal, QC, Canada) 

POSTDOCTORAT: University of California, San Francisco (UCSF, San Francisco, USA)

DOCTORAT: Physiologie, Endocrinologie Moléculaire, Université Laval (Québec, Québec, Canada)

BACCALAURÉAT: Chimie Université Laval (Québec, QC, Canada)


Professionnel de recherche

2 projets les plus récents

  • Steroid hormone synthesis/inactivation and action in terminal lung development
  • Androgen receptor activation by glucocorticoid metabolite : a novel player in the physiopathology of respiratory distress syndrome in neonates